Article
Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease.
PloS one - 1 Jan 2015
Heiman-Patterson Terry D, Blankenhorn Elizabeth P, Sher Roger B, Jiang Juliann, Welsh Priscilla, Dixon Meredith C, Jeffrey Jeremy I, Wong Philip, Cox Gregory A, Alexander Guillermo M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting motor neurons in the central nervous system. Although most cases of ALS are sporadic, about 5-10% of cases are familial (FALS) with approximately 20% of FALS caused by mutations in the Cu/Zn superoxide dismutase (SOD1) gene. We have reported that hSOD1-G93A transgenic mice modeling this disease show a more severe phenotype when...
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