Article
Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS.
Journal of the neurological sciences - 15 Sept 2005
Heiman-Patterson T D, Deitch J S, Blankenhorn E P, Erwin K L, Perreault M J, Alexander B K, Byers N, Toman I, Alexander G M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disorder. While most cases of ALS are sporadic, 10-15% are familial, and of these 15-20% possess a mutation in the gene that codes for the enzyme Cu/Zn superoxide dismutase (SOD1). In families of ALS patients with specific SOD1 mutations, affected members demonstrate significant heterogeneity of disease and a large variation in age of onset and...
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