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Article

Analysis of compound heterozygotes reveals that the mouse floxed Pax6 (tm1Ued) allele produces abnormal eye phenotypes.

Transgenic research - 1 Oct 2016

Dorà Natalie J, Crookshanks Aaron J F, Leung Karen K Y, Simpson T Ian, Mason John O, Price David J, West John D

Abstract excerpt

Analysis of abnormal phenotypes produced by different types of mutations has been crucial for our understanding of gene function. Some floxed alleles that retain a neomycin-resistance selection cassette (neo cassette) are not equivalent to wild-type alleles and provide useful experimental resources. Pax6 is an important developmental gene and the aim of this study was to determine whether the floxed Pax6 (tm1Ued)...

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Identifiers

PMID: 27240603
DOI: 10.1007/s11248-016-9962-4
PMCID: PMC5023747

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