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Article

A family-based association test to detect gene-gene interactions in the presence of linkage.

European journal of human genetics : EJHG - 1 Sept 2012

De Lobel Lizzy, Thijs Lutgarde, Kouznetsova Tatiana, Staessen Jan A, Van Steen Kristel

Abstract excerpt

For many complex diseases, quantitative traits contain more information than dichotomous traits. One of the approaches used to analyse these traits in family-based association studies is the quantitative transmission disequilibrium test (QTDT). The QTDT is a regression-based approach that models simultaneously linkage and association. It splits up the association effect in a between- and a within-family genetic...

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Identifiers

PMID: 22419171
DOI: 10.1038/ejhg.2012.45
PMCID: PMC3421128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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