Article
A novel method to identify gene-gene effects in nuclear families: the MDR-PDT.
Genetic epidemiology - 1 Feb 2006
Martin E R, Ritchie M D, Hahn L, Kang S, Moore J H
Abstract excerpt
It is now well recognized that gene-gene and gene-environment interactions are important in complex diseases, and statistical methods to detect interactions are becoming widespread. Traditional parametric approaches are limited in their ability to detect high-order interactions and handle sparse data, and standard stepwise procedures may miss interactions that occur in the absence of detectable main effects. To...
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