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Article

Limited variation in vaccine candidate Plasmodium falciparum Merozoite Surface Protein-6 over multiple transmission seasons.

Malaria journal - 24 May 2010

Neal Aaron T, Jordan Stephen J, Oliveira Ana L, Hernandez Jean N, Branch Oralee H, Rayner Julian C

Abstract excerpt

BACKGROUND: Plasmodium falciparum Merozoite Surface Protein-6 (PfMSP6) is a component of the complex proteinacious coat that surrounds P. falciparum merozoites. This location, and the presence of anti-PfMSP6 antibodies in P. falciparum-exposed individuals, makes PfMSP6 a potential blood stage vaccine target. However, genetic diversity has proven to be a major hurdle for vaccines targeting other blood stage P....

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Identifiers

PMID: 20497564
DOI: 10.1186/1475-2875-9-138
PMCID: PMC2881939

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