Article
Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin.
Vaccine - 18 Feb 2013
Tanabe Kazuyuki, Mita Toshihiro, Palacpac Nirianne M Q, Arisue Nobuko, Tougan Takahiro, Kawai Satoru, Jombart Thibaut, Kobayashi Fumie, Horii Toshihiro
Abstract excerpt
Populations of Plasmodium falciparum, the most virulent human malaria parasite, are diverse owing to wide levels of transmission and endemicity of infection. Genetic diversity of P. falciparum antigens, within and between parasite populations, remains a confounding factor in malaria pathogenesis as well as clinical trials of vaccine candidates. Variation of target antigens in parasite populations may arise from...
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