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Article

Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1).

PLoS neglected tropical diseases - 1 Jan 2013

Arnott Alicia, Mueller Ivo, Ramsland Paul A, Siba Peter M, Reeder John C, Barry Alyssa E

Abstract excerpt

BACKGROUND: The Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1) is a promising malaria vaccine candidate, however it remains unclear which regions are naturally targeted by host immunity and whether its high genetic diversity will preclude coverage by a monovalent vaccine. To assess its feasibility as a vaccine candidate, we investigated the global population structure of PvAMA1. METHODOLOGY AND PRINCIPAL...

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PMID: 24205419
DOI: 10.1371/journal.pntd.0002506
PMCID: PMC3814406

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Source receipt: pubmed, retrieved 7 Sept 2026.

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