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Article

Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru

27 May 2008

Abstract excerpt

BACKGROUND: Several of the intended Plasmodium falciparum vaccine candidate antigens are highly polymorphic and could render a vaccine ineffective if their antigenic sites were not represented in the vaccine. In this study, characterization of genetic variability was performed in major B and T-cell epitopes within vaccine candidate antigens in isolates of P. falciparum from Peru. METHODS: DNA sequencing analysis...

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PMID: 18505558
DOI: 10.1186/1475-2875-7-93

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