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Article

Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia.

Leukemia - 1 Apr 2015

Engle E K, Fisher D A C, Miller C A, McLellan M D, Fulton R S, Moore D M, Wilson R K, Ley T J, Oh S T

Abstract excerpt

Clonal architecture in myeloproliferative neoplasms (MPNs) is poorly understood. Here we report genomic analyses of a patient with primary myelofibrosis (PMF) transformed to secondary acute myeloid leukemia (sAML). Whole genome sequencing (WGS) was performed on PMF and sAML diagnosis samples, wit...

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Share to Clonal Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Primary Myelofibrosis

Share to Proto-Oncogene Proteins c-myb

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Source

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Identifiers

PMID: 25252869
DOI: 10.1038/leu.2014.289
PMCID: PMC4374044

Genes

ASXL1
IDH1
JAK2
MYB
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25252869-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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