Article
Comparison of resistance mutation patterns in historical plasma HIV RNA genotypes with those in current proviral HIV DNA genotypes among extensively treated patients with suppressed replication.
HIV medicine - 1 Oct 2012
Delaugerre C, Braun J, Charreau I, Delarue S, Nere M L, de Castro N, May T, Marchou B, Simon F, Molina J M, Aboulker J P
Abstract excerpt
OBJECTIVES: Heavily treatment-experienced patients with good virological control could be at risk of virological failure on switching to a new regimen if pre-existing drug resistance is not taken into account. We examined whether genotyping based on cellular HIV-1 DNA during controlled viraemia identifies resistance mutations detected in plasma HIV-1 RNA during treatment with previous antiretroviral regimens....
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