Article
Analysis of HIV-1 drug-resistant variants in plasma and peripheral blood mononuclear cells from untreated individuals: implications for clinical management.
The new microbiologica - 1 Jul 2007
Bon Isabella, Alessandrini Federica, Borderi Marco, Gorini Roberta, Re Maria Carla
Abstract excerpt
Genotypic resistance analysis on viral DNA and plasma was performed in 56 therapy naive patients with recent and chronic infection to assess the prevalence of mutations associated with drug resistance and compare cell-free and cell-associated strains. Direct sequencing of DNA provirus disclosed key mutations to RT inhibitors more frequently than in plasma RNA. In addition, major mutations associated with drug...
Topics
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- DNA, Viral
- Drug Resistance, Viral
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Mutation