Article
Historical HIV-RNA resistance test results are more informative than proviral DNA genotyping in cases of suppressed or residual viraemia.
The Journal of antimicrobial chemotherapy - 1 Apr 2011
Wirden Marc, Soulie Cathia, Valantin Marc-Antoine, Fourati Slim, Simon Anne, Lambert-Niclot Sidonie, Bonmarchand Manuela, Clavel-Osorio Cyril, Marcelin Anne-Genevieve, Katlama Christine, Calvez Vincent
Abstract excerpt
BACKGROUND: Resistance genotyping is often requested due to residual HIV viraemia or for treatment optimization, but may be unsuccessful if plasma RNA levels are too low or undetectable. Analyses of proviral HIV-DNA can provide information about the viral reservoir, because integrated DNA reflects both actively and latently infected cells. OBJECTIVES: To determine whether proviral DNA is a potential relevant...
Topics
- Antiviral Agents
- DNA, Viral
- Drug Resistance, Viral
- Genotype
- HIV
- HIV Infections
- Humans
- Lymphocytes
- Microbial Sensitivity Tests
- Plasma