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Article

Archived HIV-1 DNA resistance mutations to rilpivirine and etravirine in successfully treated HIV-1-infected individuals pre-exposed to efavirenz or nevirapine.

The Journal of antimicrobial chemotherapy - 1 Feb 2015

Gallien S, Charreau I, Nere M L, Mahjoub N, Simon F, de Castro N, Aboulker J P, Molina J M, Delaugerre C

Abstract excerpt

OBJECTIVES: Efavirenz and nevirapine failure is associated with a rapid selection of resistance-associated mutations (RAMs), which may impact on etravirine or rilpivirine susceptibility. However, RAMs for rilpivirine and etravirine cannot be reported on previous resistance genotypes because these specific RAMs were not analyzed at that time. Therefore, our objective was to determine, in virologically suppressed...

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Benzoxazines
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Nevirapine
Nitriles

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PMID: 25344807
DOI: 10.1093/jac/dku395

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