Current knowledge of HIV-1 reverse transcriptase mutations selected during nucleoside analogue therapy: the potential to use resistance data to guide clinical decisions.

Abstract excerpt

Massive viral turnover and the high error rate of reverse transcriptase create the potential for drug-resistant viral variants to appear rapidly under the selective pressure of antiretroviral therapy. Loss of antiviral effect in treatment compliant persons is most commonly coincident with the app...

Topics

• Anti-HIV Agents
• Drug Resistance, Microbial
• HIV Infections
• HIV Reverse Transcriptase
• HIV-1
• Humans
• Mutation
• Reverse Transcriptase Inhibitors