Article
Emerging integrase inhibitor resistance mutations in raltegravir-treated HIV-1-infected patients with low-level viremia.
AIDS (London, England) - 13 Mar 2011
Gallien Sébastien, Delaugerre Constance, Charreau Isabelle, Braun Joséphine, Boulet Thomas, Barrail-Tran Aurélie, de Castro Nathalie, Molina Jean-Michel, Kuritzkes Daniel R
Abstract excerpt
BACKGROUND: The emergence of integrase strand-transfer inhibitor (INSTI) resistance-associated mutations was examined in patients with low-level viremia after switching from enfuvirtide to raltegravir in the ANRS 138-Easier trial. METHODS: Integrase genes of plasma virus from raltegravir-treated patients in the Easier trial with low-level viremia (50-500 copies/ml) were sequenced to determine INSTI...
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