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Article

Growth assays to assess polyglutamine toxicity in yeast.

Journal of visualized experiments : JoVE - 5 Mar 2012

Duennwald Martin L

Abstract excerpt

Protein misfolding is associated with many human diseases, particularly neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Huntington's disease (HD) is caused by the abnormal expansion of a polyglutamine (polyQ) region within the protein huntingtin. The polyQ-expanded huntingtin protein attains an aberrant conformation (i.e. it misfolds) and causes cellular...

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Identifiers

PMID: 22415521
DOI: 10.3791/3461
PMCID: PMC3460590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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