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Article

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity.

Genes & development - 1 Dec 2008

Duennwald Martin L, Lindquist Susan

Abstract excerpt

Protein misfolding, whether caused by aging, environmental factors, or genetic mutations, is a common basis for neurodegenerative diseases. The misfolding of proteins with abnormally long polyglutamine (polyQ) expansions causes several neurodegenerative disorders, such as Huntington's disease (HD). Although many cellular pathways have been documented to be impaired in HD, the primary triggers of polyQ toxicity...

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PMID: 19015277
DOI: 10.1101/gad.1673408
PMCID: PMC2600758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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