Article
N-linked glycosylation of protease-activated receptor-1 at extracellular loop 2 regulates G-protein signaling bias.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015
Soto Antonio G, Smith Thomas H, Chen Buxin, Bhattacharya Supriyo, Cordova Isabel Canto, Kenakin Terry, Vaidehi Nagarajan, Trejo JoAnn
Abstract excerpt
Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by which activation of a given GPCR with the same ligand permits coupling to multiple G-protein subtypes is unclear....
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