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Article

N-glycosylation of the human neuropeptide QRFP receptor (QRFPR) is essential for ligand binding and receptor activation.

Journal of neurochemistry - 1 Jul 2021

Wang Weiwei, Tian Yanan, Shi Xiaoliu, Ma Qiang, Xu Yue, Yang Gangjie, Yi Wen, Shi Ying, Zhou Naiming

Abstract excerpt

The newly identified pyroglutamylated RFamide peptide (QRFP) signaling system has been shown to be implicated in regulating a variety of physiological processes. G-protein-coupled receptors (GPCRs) are preferentially N-glycosylated on extracellular domains. The human QRFP receptor QRFPR (GPR103) possesses three N-glycosylation consensus sites, two located on the N-terminal domain (N5 and N19) and one on the first...

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PMID: 33655503
DOI: 10.1111/jnc.15337

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