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Article

HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

PloS one - 1 Jan 2012

Stax Martijn J, Kootstra Neeltje A, van 't Wout Angélique B, Tanck Michael W T, Bakker Margreet, Pollakis Georgios, Paxton William A

Abstract excerpt

BACKGROUND: DC-SIGN expressed by dendritic cells captures HIV-1 resulting in trans-infection of CD4(+) T-lymphocytes. However, BSSL (bile-salt stimulated lipase) binding to DC-SIGN interferes with HIV-1 capture. DC-SIGN binding properties of BSSL associate with the polymorphic repeated motif of BSSL exon 11. Furthermore, BSSL binds to HIV-1 co-receptor CXCR4. We hypothesized that BSSL modulates HIV-1 disease...

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Share to CD4 Lymphocyte Count
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22412885
DOI: 10.1371/journal.pone.0032534
PMCID: PMC3295759

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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