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Article

Binding of human milk to pathogen receptor DC-SIGN varies with bile salt-stimulated lipase (BSSL) gene polymorphism.

PloS one - 28 Feb 2011

Stax Martijn J, Naarding Marloes A, Tanck Michael W T, Lindquist Susanne, Hernell Olle, Lyle Robert, Brandtzaeg Per, Eggesbø Merete, Pollakis Georgios, Paxton William A

Abstract excerpt

OBJECTIVE: Dendritic cells bind an array of antigens and DC-SIGN has been postulated to act as a receptor for mucosal pathogen transmission. Bile salt-stimulated lipase (BSSL) from human milk potently binds DC-SIGN and blocks DC-SIGN mediated trans-infection of CD4(+) T-lymphocytes with HIV-1. Objective was to study variation in DC-SIGN binding properties and the relation between DC-SIGN binding capacity of milk...

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Identifiers

PMID: 21386960
DOI: 10.1371/journal.pone.0017316
PMCID: PMC3046167

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