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Article

Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian Indians.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2008

Chaudhary Omkar, Rajsekar Kavitha, Ahmed Imran, Verma Romsha, Bala Manju, Bhasin Rama, Luthra Kalpana

Abstract excerpt

A single nucleotide polymorphism (SNP) in SDF-1, the natural ligand for the HIV-1 coreceptor CXCR4, is implicated to have protective effects against HIV-1 infection. Dendritic cells are the first to encounter HIV-1 at mucosal sites and virus binding occurs via receptors known as DC-SIGN. Variations in the number of repeats in the neck region of DC-SIGN and DC-SIGNR are reported to possibly influence host...

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Identifiers

PMID: 18775666
DOI: 10.1016/j.jcv.2008.06.005

Genes

CXCR4

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Polymorphic variants in DC-SIGN, DC-SIGNR and SDF-1 in high risk seronegative and HIV-1 patients in Northern Asian Indians.PMID 18775666Read ↗

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