Article
Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms.
European journal of human genetics : EJHG - 1 Jun 2005
Liu Huanliang, Hladik Florian, Andrus Thomas, Sakchalathorn Polachai, Lentz Gretchen M, Fialkow Michael F, Corey Lawrence, McElrath M Juliana, Zhu Tuofu
Abstract excerpt
The repeat region of DC-SIGNR (CD209L) is polymorphic on the genomic level, and, in a separate study, we observed a correlation between the DC-SIGNR genotype and HIV-1 susceptibility during sexual contact. However, previous investigations using immunohistochemistry failed to detect membrane-bound DC-SIGNR on cells in the genital and rectal mucosa. We therefore explored the presence of DC-SIGNR in these...
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