Article
Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.
PLoS pathogens - 1 Jan 2012
Hirayasu Kouyuki, Ohashi Jun, Kashiwase Koichi, Hananantachai Hathairad, Naka Izumi, Ogawa Atsuko, Takanashi Minoko, Satake Masahiro, Nakajima Kazunori, Parham Peter, Arase Hisashi, Tokunaga Katsushi, Patarapotikul Jintana, Yabe Toshio
Abstract excerpt
Cerebral malaria is a major, life-threatening complication of Plasmodium falciparum malaria, and has very high mortality rate. In murine malaria models, natural killer (NK) cell responses have been shown to play a crucial role in the pathogenesis of cerebral malaria. To investigate the role of NK cells in the developmental process of human cerebral malaria, we conducted a case-control study examining genotypes...
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