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Article

Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.

Malaria journal - 25 Feb 2021

Tukwasibwe Stephen, Traherne James A, Chazara Olympe, Jayaraman Jyothi, Trowsdale John, Moffett Ashley, Jiang Wei, Nankabirwa Joaniter I, Rek John, Arinaitwe Emmanuel, Nsobya Samuel L, Atuheirwe Maxine, Frank Mubiru, Godwin Anguzu, Jagannathan Prasanna, Cose Stephen, Kamya Moses R, Dorsey Grant, Rosenthal Philip J, Colucci Francesco, Nakimuli Annettee

Abstract excerpt

BACKGROUND: Malaria is one of the most serious infectious diseases in the world. The malaria burden is greatly affected by human immunity, and immune responses vary between populations. Genetic diversity in KIR and HLA-C genes, which are important in immunity to infectious diseases, is likely to play a role in this heterogeneity. Several studies have shown that KIR and HLA-C genes influence the immune response to...

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Identifiers

PMID: 33632228
DOI: 10.1186/s12936-021-03652-y
PMCID: PMC7908804

Genes

C2
KIR2DS1
KIR2DS5
KIR3DS1

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