Article
Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria.
Cellular & molecular immunology - 1 Aug 2020
Tukwasibwe Stephen, Nakimuli Annettee, Traherne James, Chazara Olympe, Jayaraman Jyothi, Trowsdale John, Moffett Ashley, Jagannathan Prasanna, Rosenthal Philip J, Cose Stephen, Colucci Francesco
Abstract excerpt
Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocytic Plasmodium falciparum parasites by...
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