Article
Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence.
The Journal of infectious diseases - 2 Jul 2021
Digitale Jean C, Callaway Perri C, Martin Maureen, Nelson George, Viard Mathias, Rek John, Arinaitwe Emmanuel, Dorsey Grant, Kamya Moses, Carrington Mary, Rodriguez-Barraquer Isabel, Feeney Margaret E
Abstract excerpt
Killer cell immunoglobulin-like receptors (KIRs) and their HLA ligands influence the outcome of many infectious diseases. We analyzed the relationship of compound KIR-HLA genotypes with risk of Plasmodium falciparum infection in a longitudinal cohort of 890 Ugandan individuals. We found that presence of HLA-C2 and HLA-Bw4, ligands for inhibitory KIR2DL1 and KIR3DL1, respectively, increased the likelihood of P....
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