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Article

Extracellular finger domain modulates the response of the epithelial sodium channel to shear stress.

The Journal of biological chemistry - 4 May 2012

Shi Shujie, Blobner Brandon M, Kashlan Ossama B, Kleyman Thomas R

Abstract excerpt

The epithelial sodium channel (ENaC) is regulated by multiple extracellular stimuli, including shear stress. Previous studies suggest that the extracellular finger domains of ENaC α and γ subunits contain allosteric regulatory modules. However, the role of the finger domain in the shear stress response is unknown. We examined whether mutations of specific residues in the finger domain of the α subunit altered the...

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Identifiers

PMID: 22408250
DOI: 10.1074/jbc.M112.346551
PMCID: PMC3346134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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