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Article

Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the Caenorhabditis elegans degenerin channel's response to shear stress.

The Journal of biological chemistry - 6 Jul 2018

Shi Shujie, Mutchler Stephanie M, Blobner Brandon M, Kashlan Ossama B, Kleyman Thomas R

Abstract excerpt

The Caenorhabditis elegans MEC-4/MEC-10 channel mediates the worm's response to gentle body touch and is activated by laminar shear stress (LSS) when expressed in Xenopus oocytes. Substitutions at multiple sites within the second transmembrane domain (TM2) of MEC-4 or MEC-10 abolish the gentle touch response in worms, but the roles of these residues in mechanosensing are unclear. The present study therefore...

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Identifiers

PMID: 29743244
DOI: 10.1074/jbc.RA118.002499
PMCID: PMC6036219

Genes

LSS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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