Back to search

Article

Molecular principles of Piezo1 activation by increased membrane tension

2019-10-30

Abstract excerpt

<h4>SUMMARY PARAGRAPH</h4> Piezo1 is a mechanosensitive channel involved in many cellular functions and responsible for sensing shear-stress and pressure forces in cells1–3. Piezo1 plays a critical role in the circulatory system and tissue development. Mutations on Piezo1 are linked to human diseases such as lymphedema2,4 or hematological disorders such as hemolytic anaemia5 and resistance to malaria6. Hypotheses...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9bb2d27a-0000-57df-a401-01b6ac114553
DOI
10.1101/823518
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Molecular principles of Piezo1 activation by increased membrane tensionDOI 10.1101/823518
Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators.Semantic proximity
Structure of the mechanically activated ion channel Piezo1.Semantic proximity
Regulation of PIEZO1 channel force sensitivity by interblade handshakingSemantic proximity
Structure, kinetic properties and biological function of mechanosensitive Piezo channelsSemantic proximity
Piezo1: properties of a cation selective mechanical channel.Semantic proximity
Identification and functional characterization of the Piezo1 channel pore domain.Semantic proximity
Mechanosensing by Piezo1 and its implications for physiology and various pathologiesSemantic proximity
Voltage-gating of mechanosensitive PIEZO channelsSemantic proximity
Levering Mechanically Activated Piezo Channels for Potential Pharmacological InterventionSemantic proximity
A disease mutation reveals a non-swapped pore and rewired gating cycle of the mechanically activated PIEZO1 channelSemantic proximity
The Form and Function of PIEZO2Semantic proximity
The Kinetics and the Permeation Properties of Piezo Channels.Semantic proximity
Select a neighboring publication to make it the new centre.