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Article

Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress.

American journal of physiology. Renal physiology - 1 May 2011

Abi-Antoun Tania, Shi Shujie, Tolino Lindsey A, Kleyman Thomas R, Carattino Marcelo D

Abstract excerpt

Na(+) absorption and K(+) secretion in the distal segments of the nephron are modulated by the tubular flow rate. Epithelial Na(+) channels (ENaC), composed of α-, β-, and γ-subunits respond to laminar shear stress (LSS) with an increase in open probability. Higher vertebrates express a δ-ENaC subunit that is functionally related to the α-subunit, while sharing only 35% of sequence identity. We investigated the...

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Share to Epithelial Sodium Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21307123
DOI: 10.1152/ajprenal.00610.2010
PMCID: PMC3094055

Genes

LSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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