Article

EGFR-Mediated Mechanotransduction in Aortic Valve Cells: A Key Pathway in Response to Wall Shear Stress

2025-03-13

Abstract excerpt

<h4>Aim</h4> Blood flow-induced mechanical forces, particularly wall shear stress (WSS), play a fundamental role in aortic valve remodeling and maturation. Dysregulation of these processes contributes to age-related valve diseases, such as aortic stenosis and regurgitation. While epidermal growth factor receptor (EGFR) signaling has been implicated in valve development, its role in mechanotransduction remains unc...

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Literature Corpus work: 6a942b44-e419-5128-9f16-1df2c9e0c747
DOI: 10.1101/2025.03.10.642402

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