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Article

Mutations in the pore region modify epithelial sodium channel gating by shear stress.

The Journal of biological chemistry - 11 Feb 2005

Carattino Marcelo D, Sheng Shaohu, Kleyman Thomas R

Abstract excerpt

Previous studies have shown that epithelial Na+ channels (ENaCs) are activated by laminar shear stress (LSS). ENaCs with a high intrinsic open probability because of a mutation (betaS518K) or covalent modification of an introduced Cys residue (alphaS580C) in the pre-second transmembrane domain (p...

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Source

Identifiers

PMID: 15569663
DOI: 10.1074/jbc.M413123200

Genes

LSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569663-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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