Article
Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.
Science (New York, N.Y.) - 30 Sept 2005
McGee Aaron W, Yang Yupeng, Fischer Quentin S, Daw Nigel W, Strittmatter Stephen M
Abstract excerpt
Monocular deprivation normally alters ocular dominance in the visual cortex only during a postnatal critical period (20 to 32 days postnatal in mice). We find that mutations in the Nogo-66 receptor (NgR) affect cessation of ocular dominance plasticity. In NgR-/- mice, plasticity during the critical period is normal, but it continues abnormally such that ocular dominance at 45 or 120 days postnatal is subject to...
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