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Article

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

Nature neuroscience - 1 Mar 2004

Mi Sha, Lee Xinhua, Shao Zhaohui, Thill Greg, Ji Benxiu, Relton Jane, Levesque Melissa, Allaire Norm, Perrin Steve, Sands Bryan, Crowell Thomas, Cate Richard L, McCoy John M, Pepinsky R Blake

Abstract excerpt

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit (the neurotrophin receptor p75). However, in reconstituted non-neuronal systems, NgR1 and p75 together are unable to activate RhoA, suggesting that additional...

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Identifiers

PMID: 14966521
DOI: 10.1038/nn1188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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