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Article

Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Dec 2008

Budel Stéphane, Padukkavidana Thihan, Liu Betty P, Feng Zeny, Hu Fenghua, Johnson Sam, Lauren Juha, Park James H, McGee Aaron W, Liao Ji, Stillman Althea, Kim Ji-Eun, Yang Bao-Zhu, Sodi Stefano, Gelernter Joel, Zhao Hongyu, Hisama Fuki, Arnsten Amy F T, Strittmatter Stephen M

Abstract excerpt

In schizophrenia, genetic predisposition has been linked to chromosome 22q11 and myelin-specific genes are misexpressed in schizophrenia. Nogo-66 receptor 1 (NGR or RTN4R) has been considered to be a 22q11 candidate gene for schizophrenia susceptibility because it encodes an axonal protein that mediates myelin inhibition of axonal sprouting. Confirming previous studies, we found that variation at the NGR locus is...

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Identifiers

PMID: 19052207
DOI: 10.1523/JNEUROSCI.3828-08.2008
PMCID: PMC2892845

Genes

RTN4R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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