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Article

Enzyme-free amplified detection of DNA by an autonomous ligation DNAzyme machinery.

Journal of the American Chemical Society - 28 Mar 2012

Wang Fuan, Elbaz Johann, Willner Itamar

Abstract excerpt

The Zn(2+)-dependent ligation DNAzyme is implemented as a biocatalyst for the amplified detection of a target DNA by the autonomous replication of a nucleic acid reporter unit that is generated by the catalyzed ligation process. The reporter units enhance the formation of active DNAzyme units, thus leading to the isothermal autocatalytic formation of the reporter elements. The system was further developed and...

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PMID: 22404383
DOI: 10.1021/ja300616w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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