Article
Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer.
Biosensors & bioelectronics - 15 Feb 2023
Habimana Jean de Dieu, Mukama Omar, Chen Guiquan, Chen Mengjun, Amissah Obed Boadi, Wang Lin, Liu Yujie, Sun Yirong, Li Amy L, Deng Sihao, Huang Jufang, Yan Xiao-Xin, Rutaganda Theobard, Mutangana Dieudonne, Wu Lin-Ping, Huang Rongqi, Li Zhiyuan
Abstract excerpt
Developing rapid and non-invasive diagnostics for Helicobacter pylori (HP) is imperative to prevent associated diseases such as stomach gastritis, ulcers, and cancers. Owing to HP strain heterogeneity, not all HP-infected individuals incur side effects. Cytotoxin-associated gene A (CagA), and vacuolating cytotoxin A (VacA) genes predominantly drive HP pathogenicity. Therefore, diagnosing CagA and VacA genotypes...
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