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Article

An autonomous fueled machine that replicates catalytic nucleic acid templates for the amplified optical analysis of DNA.

Nature protocols - 1 Jan 2006

Weizmann Yossi, Cheglakov Zoya, Pavlov Valeri, Willner Itamar

Abstract excerpt

Here we describe a protocol for the amplified detection of a target DNA using a DNA/FokI-based replicating cutting machine. The protocol is based on the design of a sensing hairpin oligonucleotide that is opened upon hybridization with the analyte DNA. The endonuclease FokI binds to the double-stranded complex and cleaves it to a "cutter" unit. The "cutter" unit reacts with a fuel oligonucleotide to generate and...

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Identifiers

PMID: 17406281
DOI: 10.1038/nprot.2006.78

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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