Article
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes.
Human molecular genetics - 15 Jun 2012
Wallace Chris, Rotival Maxime, Cooper Jason D, Rice Catherine M, Yang Jennie H M, McNeill Mhairi, Smyth Deborah J, Niblett David, Cambien François, Tiret Laurence, Todd John A, Clayton David G, Blankenberg Stefan
Abstract excerpt
One mechanism by which disease-associated DNA variation can alter disease risk is altering gene expression. However, linkage disequilibrium (LD) between variants, mostly single-nucleotide polymorphisms (SNPs), means it is not sufficient to show that a particular variant associates with both disease and expression, as there could be two distinct causal variants in LD. Here, we describe a formal statistical test of...
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