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Article

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans.

PLoS genetics - 1 Dec 2011

Rotival Maxime, Zeller Tanja, Wild Philipp S, Maouche Seraya, Szymczak Silke, Schillert Arne, Castagné Raphaele, Deiseroth Arne, Proust Carole, Brocheton Jessy, Godefroy Tiphaine, Perret Claire, Germain Marine, Eleftheriadis Medea, Sinning Christoph R, Schnabel Renate B, Lubos Edith, Lackner Karl J, Rossmann Heidi, Münzel Thomas, Rendon Augusto, Erdmann Jeanette, Deloukas Panos, Hengstenberg Christian, Diemert Patrick, Montalescot Gilles, Ouwehand Willem H, Samani Nilesh J, Schunkert Heribert, Tregouet David-Alexandre, Ziegler Andreas, Goodall Alison H, Cambien François, Tiret Laurence, Blankenberg Stefan

Abstract excerpt

One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms may play a more prominent role in disease susceptibility. We analyzed 12,808 genes detected in at least 5% of...

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Source

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Identifiers

PMID: 22144904
DOI: 10.1371/journal.pgen.1002367
PMCID: PMC3228821

Genes

CRIP1
LYZ
MADCAM1
RPS26
SUOX
YEATS4

Variants

rs11171739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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