Article
BRCA1 promoter methylation in peripheral blood DNA was identified in sporadic breast cancer and controls.
Cancer epidemiology - 1 Jun 2012
Bosviel Rémy, Garcia Stéphane, Lavediaux Guillaume, Michard Emilie, Dravers Marine, Kwiatkowski Fabrice, Bignon Yves-Jean, Bernard-Gallon Dominique J
Abstract excerpt
OBJECTIVE: Epigenetics, particularly DNA methylation, has recently been shown to be important in breast cancer initiation. We investigated the clinical and prognostic importance of whole blood breast cancer early onset gene 1 (BRCA1) DNA methylation in sporadic breast cancer. METHODS: Genomic DNA was extracted from the peripheral blood cells (PBCs) of 902 breast cancer patients at diagnosis, with no BRCA1...
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