Article
Epigenome-wide association study of breast cancer using prospectively collected sister study samples.
Journal of the National Cancer Institute - 15 May 2013
Xu Zongli, Bolick Sophia C E, DeRoo Lisa A, Weinberg Clarice R, Sandler Dale P, Taylor Jack A
Abstract excerpt
BACKGROUND: Previous studies have suggested DNA methylation in blood is a potential epigenetic marker of cancer risk, but this has not been evaluated on a genome-wide scale in prospective studies for breast cancer. METHODS: We measured DNA methylation at 27578 CpGs in blood samples from 298 women who developed breast cancer 0 to 5 years after enrollment in the Sister Study cohort and compared them with a random...
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