Article
Methylation profiles of the BRCA1 promoter in hereditary and sporadic breast cancer among Han Chinese.
Medical oncology (Northwood, London, England) - 1 Sept 2012
Pang Da, Zhao Yashuang, Xue Weinan, Shan Ming, Chen Yanbo, Zhang Youxue, Zhang Guoqiang, Liu Feng, Li Dalin, Yang Yanmei
Abstract excerpt
The development of breast cancer is a multistep process associated with complex changes in host gene expression patterns including inactivation of tumor suppressor genes and activation of oncogenes. Critically, hereditary predisposition plays a significant role in cancer susceptibility. However, mutation of the BRCA1 gene is found only in the minority of hereditary breast cancer, which indicates that there might...
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