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Article

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype.

Breast cancer research : BCR - 1 Jan 2008

Snell Cameron, Krypuy Michael, Wong Ee Ming, Loughrey Maurice B, Dobrovic Alexander

Abstract excerpt

INTRODUCTION: Individuals with germline mutations in the BRCA1 gene have an elevated risk of developing breast cancer, and often display characteristic clinicopathological features. We hypothesised that inactivation of BRCA1 by promoter methylation could occur as a germline or an early somatic event that predisposes to breast cancer with the phenotype normally associated with BRCA1 germline mutation. METHODS: We...

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Source

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Identifiers

PMID: 18269736
DOI: 10.1186/bcr1858
PMCID: PMC2374968

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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