Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene variations in sex hormone pathways and the risk of testicular germ cell tumour: a case-parent triad study in a Norwegian-Swedish population.

Human reproduction (Oxford, England) - 1 May 2012

Kristiansen W, Andreassen K E, Karlsson R, Aschim E L, Bremnes R M, Dahl O, Fosså S D, Klepp O, Langberg C W, Solberg A, Tretli S, Adami H-O, Wiklund F, Grotmol T, Haugen T B

Abstract excerpt

BACKGROUND: Testicular germ cell tumour (TGCT) is the most common cancer in young men, and an imbalance between the estrogen and androgen levels in utero is hypothesized to influence TGCT risk. Thus, polymorphisms in genes involved in the action of sex hormones may contribute to variability in an individual's susceptibility to TGCT. METHODS: We conducted a Norwegian-Swedish case-parent study. A total of 105...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aromatase
Share to Estrogen Receptor beta

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gonadal Steroid Hormones

Share to Neoplasms, Germ Cell and Embryonal

Share to Norway

Share to Risk Assessment

Share to Sweden

Share to Testicular Neoplasms

Source

Identifiers

PMID: 22402210
DOI: 10.1093/humrep/des075

Genes

ESR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene variations in sex hormone pathways and the risk of testicular germ cell tumour: a case-parent triad study in a Norwegian-Swedish population.PMID 22402210Read ↗

Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes.Semantic proximity Read ↗

Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer.Semantic proximity Read ↗

Risk of testicular germ cell cancer in relation to variation in maternal and offspring cytochrome p450 genes involved in catechol estrogen metabolism.Semantic proximity Read ↗

Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour.Semantic proximity Read ↗

Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor.Semantic proximity Read ↗

Variations in testosterone pathway genes and susceptibility to testicular cancer in Norwegian men.Semantic proximity Read ↗

Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease.Semantic proximity Read ↗

Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application.Semantic proximity Read ↗

Epidemiology and Risk Factors for Testicular Cancer: A Systematic Review.Semantic proximity Read ↗

Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.Semantic proximity Read ↗

Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors.Semantic proximity Read ↗

CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.