Article
Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor.
Human molecular genetics - 15 Jul 2015
Kristiansen Wenche, Karlsson Robert, Rounge Trine B, Whitington Thomas, Andreassen Bettina K, Magnusson Patrik K, Fosså Sophie D, Adami Hans-Olov, Turnbull Clare, Haugen Trine B, Grotmol Tom, Wiklund Fredrik
Abstract excerpt
Genome-wide association (GWA) studies have reported 19 distinct susceptibility loci for testicular germ cell tumor (TGCT). A GWA study for TGCT was performed by genotyping 610 240 single-nucleotide polymorphisms (SNPs) in 1326 cases and 6687 controls from Sweden and Norway. No novel genome-wide significant associations were observed in this discovery stage. We put forward 27 SNPs from 15 novel regions and 12 SNPs...
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