Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.

Human molecular genetics - 15 Aug 2013

Karlsson Robert, Andreassen Kristine E, Kristiansen Wenche, Aschim Elin L, Bremnes Roy M, Dahl Olav, Fosså Sophie D, Klepp Olbjørn, Langberg Carl W, Solberg Arne, Tretli Steinar, Magnusson Patrik K E, Adami Hans-Olov, Haugen Trine B, Grotmol Tom, Wiklund Fredrik

Abstract excerpt

Recent genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) associated with testicular germ cell tumor (TGCT) risk in the genes ATF7IP, BAK1, DMRT1, KITLG, SPRY4 and TERT. In the present study, we validate these associations in a Scandinavian population, and explore effect modification by parental sex and differences in associations between the major histological subtypes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2 Homologous Antagonist-Killer Protein
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Germ Cell and Embryonal

Share to Nerve Tissue Proteins

Share to Parents

Share to Seminoma

Share to Telomerase

Share to Testicular Neoplasms

Source

Identifiers

PMID: 23640991
DOI: 10.1093/hmg/ddt188

Genes

SPRY4
BAK1
DMRT1
KITLG
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.PMID 23640991Read ↗

Replication of genetic susceptibility loci for testicular germ cell cancer in the Croatian population.Semantic proximity Read ↗

A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.Semantic proximity Read ↗

Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group.Semantic proximity Read ↗

The clinical utility of testicular cancer risk lociSemantic proximity Read ↗

Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer.Semantic proximity Read ↗

Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors.Semantic proximity Read ↗

Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.Semantic proximity Read ↗

Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour.Semantic proximity Read ↗

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.Semantic proximity Read ↗

Familial testicular germ cell tumours.Semantic proximity Read ↗

Identification of four new susceptibility loci for testicular germ cell tumour.Semantic proximity Read ↗

Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.