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Article

Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects.

The international journal of neuropsychopharmacology - 1 Feb 2013

Weerts Elise M, McCaul Mary E, Kuwabara Hiroto, Yang Xiaoju, Xu Xiaoqiang, Dannals Robert F, Frost J James, Wong Dean F, Wand Gary S

Abstract excerpt

The Asn40Asp variant (A118G) of the μ opioid receptor (OPRM1) gene is thought to contribute to the development and treatment of alcohol dependence. Employing positron emission tomography (PET), we first examined whether the single nucleotide polymorphism (SNP) modifies binding potential (BP(ND)) of the μ-selective ligand [(11)C]carfentanil in healthy control (Con) and 5-d abstinent alcohol-dependent (AD) subjects...

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Identifiers

PMID: 22397905
DOI: 10.1017/S146114571200017X

Genes

OPRM1

Variants

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Influence of OPRM1 Asn40Asp variant (A118G) on [11C]carfentanil binding potential: preliminary findings in human subjects.PMID 22397905Read ↗

Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers.Semantic proximity Read ↗

The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.Semantic proximity Read ↗

Genetic-epigenetic interaction modulates μ-opioid receptor regulation.Semantic proximity Read ↗

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.Semantic proximity Read ↗

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.Semantic proximity Read ↗

A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.Semantic proximity Read ↗

Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.Semantic proximity Read ↗

Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues.Semantic proximity Read ↗

The μ-opioid receptor and treatment response to naltrexone.Semantic proximity Read ↗

Suppression of alcohol preference by naltrexone in the rhesus macaque: a critical role of genetic variation at the micro-opioid receptor gene locus.Semantic proximity Read ↗

Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.Semantic proximity Read ↗

Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.Semantic proximity Read ↗

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